What the FDA labels say about taking them together
Darunavir and norethindrone
Darunavir's FDA label of August 29, 2025 names norethindrone in its drug interactions section, and norethindrone's label names darunavir too. The darunavir label: “For co-administration with drospirenone, clinical monitoring is recommended due to the potential for hyperkalemia. No data are available to make recommendations on co-administration with other hormonal contraceptives.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the norethindrone FDA label on DailyMed (effective January 31, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the darunavir label say about norethindrone?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: ethinyl estradiol, norethindrone, drospirenone; Effect on Concentration of Darunavir Or Concomitant Drug: ↓ ethinyl estradiol ↓ norethindrone drospirenone: effects unknown; Clinical Comment: For co-administration with drospirenone, clinical monitoring is recommended due to the potential for hyperkalemia. No data are available to make recommendations on co-administration with other hormonal contraceptives.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the norethindrone label say about darunavir?
Norethindrone label, drug interactionsSignificant decreases in systemic concentrations of progestin have been noted in cases of co-administration with some HIV protease inhibitors (e.g., nelfinavir, ritonavir, darunavir/ritonavir, (fos)amprenavir/ritonavir, lopinavir/ritonavir, and tipranavir/ritonavir), some HCV protease inhibitors (e.g., boceprevir and telaprevir), and some non-nucleoside reverse transcriptase inhibitors (e.g., nevirapine, efavirenz).
Source: FDA drug label (Norethindrone), Glenmark Pharmaceuticals Inc., USA, effective January 31, 2026 (SPL set 0d2f8fea-3675-40d2-afd9-9fcb148dbd4b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Norethindrone | |
|---|---|---|
| Labeled for | HIV | Birth control |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.290 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once