What the FDA labels say about taking them together
Darunavir and nilotinib
Darunavir's FDA label of August 29, 2025 names nilotinib in its drug interactions section; the nilotinib labels PlainMeds reads (4) do not name darunavir. The darunavir label: “A decrease in the dosage or an adjustment of the dosing interval of dasatinib and nilotinib may be necessary for patients. Please refer to the dasatinib and nilotinib prescribing information for dosing instructions.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the nilotinib FDA label on DailyMed (effective December 16, 2025, Novartis Pharmaceuticals Corporation).
What does the darunavir label say about nilotinib?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: Antineoplastics: dasatinib, nilotinib; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ antineoplastics; Clinical Comment: A decrease in the dosage or an adjustment of the dosing interval of dasatinib and nilotinib may be necessary for patients. Please refer to the dasatinib and nilotinib prescribing information for dosing instructions.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the nilotinib label say about darunavir?
Nilotinib's label (effective December 16, 2025) and its 3 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tasigna), Novartis Pharmaceuticals Corporation, effective December 16, 2025 (SPL set 6093952a-5248-45cb-ad17-33716a411146), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Nilotinib | |
|---|---|---|
| Labeled for | HIV | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once