Darunavir and Mometasone Interaction
Drug interaction information between Darunavir and Mometasone.
Darunavir and Mometasone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Darunavir and Mometasone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Darunavir slows down how fast your body gets rid of mometasone, which can cause the steroid to reach dangerously high levels.
What To Do
Your doctor should monitor you for signs of too much steroid in your body or consider using a different medicine.
FDA Label Information
betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone ↑ corticosteroids Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Mometasone Also Interacts With
- Nirmatrelvir/Ritonavir moderate
- Mometasone Topical minor
Frequently Asked Questions
Can I take Darunavir and Mometasone together?
This is a moderate interaction. Your doctor should monitor you for signs of too much steroid in your body or consider using a different medicine.
How serious is the interaction between Darunavir and Mometasone?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Darunavir and Mometasone interact?
Darunavir slows down how fast your body gets rid of mometasone, which can cause the steroid to reach dangerously high levels.
Understanding the Darunavir and Mometasone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Darunavir belongs to the HIV Protease Inhibitor class and Mometasone belongs to the Inhaled Corticosteroid class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Darunavir slows down how fast your body gets rid of mometasone, which can cause the steroid to reach dangerously high levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Darunavir has 101 total documented interactions on file in this dataset, and Mometasone has 3. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor you for signs of too much steroid in your body or consider using a different medicine. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Darunavir or Mometasone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.