Darunavir and Mometasone Interaction
Drug interaction information between Darunavir and Mometasone.
Darunavir and Mometasone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Darunavir and Mometasone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir slows down how fast your body gets rid of mometasone, which can cause the steroid to reach dangerously high levels.
FDA Label Information
betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone ↑ corticosteroids Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Mometasone Also Interacts With
- Nirmatrelvir/Ritonavir moderate
- Mometasone Topical minor
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Mometasone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Mometasone's 3. In the moderate band specifically: Darunavir has 16 (also Omeprazole, Fluticasone, Apixaban, Clopidogrel); Mometasone has 2 (also Nirmatrelvir/Ritonavir).
What mechanism field is on file for Darunavir and Mometasone?
Darunavir slows down how fast your body gets rid of mometasone, which can cause the steroid to reach dangerously high levels.
Darunavir carries more major-labeled pairs than Mometasone
SPL source-record counts only. This page's band is moderate · classes on file: Darunavir (HIV Protease Inhibitor); Mometasone (Inhaled Corticosteroid).
Darunavir has 15 major-labeled pairs vs Mometasone's 0. This page itself is in the moderate band, not the major band.
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Omeprazole
- Fluticasone
- Apixaban
- Clopidogrel
0 major · 2 moderate · 1 minor · 3 total
- Other moderate peers for Mometasone
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.