Darunavir and Methylprednisolone Interaction
Drug interaction information between Darunavir and Methylprednisolone.
Darunavir and Methylprednisolone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Darunavir and Methylprednisolone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir stops the body from breaking down methylprednisolone, which causes the steroid to build up to high levels. This can lead to serious hormone problems like Cushing's syndrome.
FDA Label Information
betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone ↑ corticosteroids Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Methylprednisolone Also Interacts With
- Theophylline major
- Aspirin moderate
- Ketoconazole moderate
- Aprepitant moderate
- Clarithromycin moderate
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Methylprednisolone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Methylprednisolone's 29. In the moderate band specifically: Darunavir has 16 (also Omeprazole, Fluticasone, Apixaban, Clopidogrel); Methylprednisolone has 6 (also Aspirin, Ketoconazole, Aprepitant, Clarithromycin).
What mechanism field is on file for Darunavir and Methylprednisolone?
Darunavir stops the body from breaking down methylprednisolone, which causes the steroid to build up to high levels. This can lead to serious hormone problems like Cushing's syndrome.
Darunavir carries more major-labeled pairs than Methylprednisolone
SPL source-record counts only. This page's band is moderate · classes on file: Darunavir (HIV Protease Inhibitor); Methylprednisolone (Corticosteroid).
Darunavir has 15 major-labeled pairs vs Methylprednisolone's 1. This page itself is in the moderate band, not the major band.
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Omeprazole
- Fluticasone
- Apixaban
- Clopidogrel
1 major · 6 moderate · 22 minor · 29 total
- Other moderate peers for Methylprednisolone
- Aspirin
- Ketoconazole
- Aprepitant
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.