What the FDA labels say about taking them together
Darunavir and glecaprevir/pibrentasvir
Darunavir's FDA label of August 29, 2025 names glecaprevir/pibrentasvir in its drug interactions section, and glecaprevir/pibrentasvir's label names darunavir too. The glecaprevir/pibrentasvir label: “Coadministration is not recommended.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the glecaprevir/pibrentasvir FDA label on DailyMed (effective June 25, 2025, AbbVie Inc.).
What does the darunavir label say about glecaprevir/pibrentasvir?
Darunavir label, drug interactionsHepatitis C virus (HCV): Direct-Acting Antivirals: elbasvir/grazoprevir ↑ elbasvir/grazoprevir Co-administration is contraindicated due to potential for the increased risk of alanine transaminase (ALT) elevations. glecaprevir/pibrentasvir ↑ glecaprevir ↑ pibrentasvir Co-administration of PREZISTA/ritonavir with glecaprevir/pibrentasvir is not recommended.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the glecaprevir/pibrentasvir label say about darunavir?
Glecaprevir/pibrentasvir label, drug interactionsConcomitant Drug Class/Drug Name: Darunavir Lopinavir Ritonavir; Effect on Concentration: ↑ glecaprevir ↑ pibrentasvir; Clinical Comments: Coadministration is not recommended.
Source: FDA drug label (Mavyret), AbbVie Inc., effective June 25, 2025 (SPL set 7bf99777-0401-9095-8645-16c6e907fcc0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Glecaprevir/pibrentasvir | |
|---|---|---|
| Labeled for | HIV | Hepatitis C |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $152.98 per tablet 100-40 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once