What the FDA labels say about taking them together
Darunavir and fentanyl
Darunavir's FDA label of August 29, 2025 names fentanyl in its drug interactions section; the fentanyl labels PlainMeds reads (2) do not name darunavir. The darunavir label: “Careful monitoring of therapeutic effects and adverse reactions associated with CYP3A-metabolized narcotic analgesics is recommended with co-administration.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the fentanyl FDA label on DailyMed (effective March 6, 2026, Hikma Pharmaceuticals USA Inc.).
What does the darunavir label say about fentanyl?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: e.g. fentanyl, oxycodone; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ fentanyl ↑ oxycodone; Clinical Comment: Careful monitoring of therapeutic effects and adverse reactions associated with CYP3A-metabolized narcotic analgesics (including potentially fatal respiratory depression) is recommended with co-administration.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the fentanyl label say about darunavir?
Fentanyl's label (effective March 6, 2026) and its 1 other brand-application label do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fentanyl Citrate), Hikma Pharmaceuticals USA Inc., effective March 6, 2026 (SPL set ce5db1c2-feb1-4ad2-847a-d02e865bd47e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Fentanyl | |
|---|---|---|
| Labeled for | HIV | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $1.79 per mL 100 mcg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once