What the FDA labels say about taking them together
Darunavir and estazolam
Darunavir's FDA label of August 29, 2025 names estazolam in its drug interactions section; the estazolam label PlainMeds reads does not name darunavir. The darunavir label: “Titration is recommended when co-administering PREZISTA/ritonavir with sedatives/hypnotics metabolized by CYP3A and a lower dose of the sedatives/hypnotics should be considered with monitoring for adverse events.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the estazolam FDA label on DailyMed (effective November 11, 2022, Novitium Pharma LLC).
What does the darunavir label say about estazolam?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: metabolized by CYP3A e.g. buspirone, diazepam, estazolam, zolpidem; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ sedatives/hypnotics; Clinical Comment: Titration is recommended when co-administering PREZISTA/ritonavir with sedatives/hypnotics metabolized by CYP3A and a lower dose of the sedatives/hypnotics should be considered with monitoring for adverse events.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the estazolam label say about darunavir?
Estazolam's label (effective November 11, 2022) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Estazolam), Novitium Pharma LLC, effective November 11, 2022 (SPL set e1c77eb1-9cba-4e89-a03f-9fb797add4f0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Estazolam | |
|---|---|---|
| Labeled for | HIV | Insomnia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $0.839 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once