What the FDA labels say about taking them together
Darunavir and drospirenone
Darunavir's FDA label of August 29, 2025 names drospirenone in its drug interactions section; the drospirenone label PlainMeds reads does not name darunavir. The darunavir label: “For co-administration with drospirenone, clinical monitoring is recommended due to the potential for hyperkalemia. No data are available to make recommendations on co-administration with other hormonal contraceptives.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the drospirenone FDA label on DailyMed (effective August 27, 2026, Exeltis USA, Inc.).
What does the darunavir label say about drospirenone?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: ethinyl estradiol, norethindrone, drospirenone; Effect on Concentration of Darunavir Or Concomitant Drug: ↓ ethinyl estradiol ↓ norethindrone drospirenone: effects unknown; Clinical Comment: For co-administration with drospirenone, clinical monitoring is recommended due to the potential for hyperkalemia. No data are available to make recommendations on co-administration with other hormonal contraceptives.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the drospirenone label say about darunavir?
Drospirenone's label (effective August 27, 2026) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SLYND), Exeltis USA, Inc., effective August 27, 2026 (SPL set db32bc55-f295-4d87-9dbb-0a2f45573dcf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Drospirenone | |
|---|---|---|
| Labeled for | HIV | Birth control |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $6.61 per tablet 4 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once