What the FDA labels say about taking them together
Buspirone and darunavir
Darunavir's FDA label of August 29, 2025 names buspirone in its drug interactions section; the buspirone label PlainMeds reads does not name darunavir. The darunavir label: “Titration is recommended when co-administering PREZISTA/ritonavir with sedatives/hypnotics metabolized by CYP3A and a lower dose of the sedatives/hypnotics should be considered with monitoring for adverse events.”
Check it at the source: the buspirone FDA label on DailyMed (effective December 22, 2023, Unichem Pharmaceuticals (USA), Inc.); the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP).
What does the buspirone label say about darunavir?
Buspirone's label (effective December 22, 2023) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Buspirone Hydrochloride), Unichem Pharmaceuticals (USA), Inc., effective December 22, 2023 (SPL set a6bdf140-075e-445e-a62d-633a4b97f3a8), via openFDA; the full label on DailyMed
What does the darunavir label say about buspirone?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: metabolized by CYP3A e.g. buspirone, diazepam, estazolam, zolpidem; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ sedatives/hypnotics; Clinical Comment: Titration is recommended when co-administering PREZISTA/ritonavir with sedatives/hypnotics metabolized by CYP3A and a lower dose of the sedatives/hypnotics should be considered with monitoring for adverse events.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Buspirone | Darunavir | |
|---|---|---|
| Labeled for | Anxiety | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.043 per tablet 15 mg tablet | $1.16 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once