What the FDA labels say about taking them together
Betamethasone and darunavir
Darunavir's FDA label of August 29, 2025 names betamethasone in its drug interactions section; the betamethasone labels PlainMeds reads (4) do not name darunavir. The darunavir label: “Co-administration with corticosteroids of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression. …”
Check it at the source: the betamethasone FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP).
What does the betamethasone label say about darunavir?
Betamethasone's label (effective January 28, 2026) and its 3 other brand-application labels do not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Betamethasone Valerate), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set 0b386ccc-a2d4-4d18-a2d7-e46ff894c674), via openFDA; the full label on DailyMed
What does the darunavir label say about betamethasone?
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: Corticosteroids primarily metabolized by CYP3A: e.g. betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ corticosteroids; Clinical Comment: Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression. …
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Betamethasone | Darunavir | |
|---|---|---|
| Labeled for | Asthma, Eczema (atopic dermatitis), Anemia, Leukemia, lymphoma and myeloma, Multiple sclerosis, Psoriasis | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.418 per gram 0.05% cream | $1.16 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once