What the FDA labels say about taking them together
Alfuzosin and darunavir
Darunavir's FDA label of August 29, 2025 names alfuzosin in its contraindications section; the alfuzosin label PlainMeds reads does not name darunavir. The darunavir label: “Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as hypotension.”
Check it at the source: the alfuzosin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP).
What does the alfuzosin label say about darunavir?
Alfuzosin's label (effective December 5, 2024) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Uroxatral), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set 9fc7f119-f36b-44cf-945d-940160f3afe3), via openFDA; the full label on DailyMed
What does the darunavir label say about alfuzosin?
Darunavir label, contraindicationsAlpha 1-adrenoreceptor antagonist: alfuzosin Anti-gout: colchicine, in patients with renal and/or hepatic impairment Antimycobacterial: rifampin Antipsychotics: lurasidone, pimozide Cardiac Disorders: dronedarone, ivabradine, ranolazine Ergot derivatives, e.g. dihydroergotamine, ergotamine, methylergonovine Herbal product:
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: alfuzosin; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ alfuzosin; Clinical Comment: Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as hypotension.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Alfuzosin | Darunavir | |
|---|---|---|
| Labeled for | Enlarged prostate (BPH) | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.105 per tablet 10 mg tablet | $1.16 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once