What the FDA labels say about taking them together
Darbepoetin alfa and methoxy polyethylene glycol-epoetin beta
Methoxy polyethylene glycol-epoetin beta's FDA label of August 14, 2026 names darbepoetin alfa in its warnings and precautions section; the darbepoetin alfa label PlainMeds reads does not name methoxy polyethylene glycol-epoetin beta. The methoxy polyethylene glycol-epoetin beta label: “The design and overall results of the 3 large trials comparing higher and lower hemoglobin targets are shown in Table 4.”
Check it at the source: the darbepoetin alfa FDA label on DailyMed (effective July 7, 2026, Amgen, Inc); the methoxy polyethylene glycol-epoetin beta FDA label on DailyMed (effective August 14, 2026, Vifor (International) Inc.).
What does the darbepoetin alfa label say about methoxy polyethylene glycol-epoetin beta?
Darbepoetin alfa's label (effective July 7, 2026) does not name methoxy polyethylene glycol-epoetin beta in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ARANESP), Amgen, Inc, effective July 7, 2026 (SPL set 0fd36cb9-c4f6-4167-93c9-8530865db3f9), via openFDA; the full label on DailyMed
What does the methoxy polyethylene glycol-epoetin beta label say about darbepoetin alfa?
Methoxy polyethylene glycol-epoetin beta label, warnings and precautionsThe design and overall results of the 3 large trials comparing higher and lower hemoglobin targets are shown in Table 4 (Normal Hematocrit Study (NHS), Correction of Hemoglobin Outcomes in Renal Insufficiency (CHOIR) and Trial to Reduce Cardiovascular Events with Aranesp ® Therapy (TREAT)).
Source: FDA drug label (Mircera), BLA125164 (Hoffman-La Roche), as published by Vifor (International) Inc., effective August 14, 2026 (SPL set 22c56f2a-f73c-60e7-e054-00144ff88e88), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darbepoetin alfa | Methoxy polyethylene glycol-epoetin beta | |
|---|---|---|
| Labeled for | Anemia | Anemia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $446.58 per mL 25 mcg/0.42 mL syring | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once