What the FDA labels say about taking them together
Daratumumab/hyaluronidase and dexamethasone
Daratumumab/hyaluronidase's FDA label of September 3, 2026 names dexamethasone in its warnings and precautions section; the dexamethasone labels PlainMeds reads (4) do not name daratumumab/hyaluronidase. The daratumumab/hyaluronidase label: “… received DARZALEX FASPRO in combination with bortezomib, cyclophosphamide and dexamethasone.”
Check it at the source: the daratumumab/hyaluronidase FDA label on DailyMed (effective September 3, 2026); the dexamethasone FDA label on DailyMed (effective June 6, 2025, Hikma Pharmaceuticals USA, Inc.).
What does the daratumumab/hyaluronidase label say about dexamethasone?
Daratumumab/hyaluronidase label, warnings and precautionsToxicity in Patients with Light Chain (AL) Amyloidosis Serious or fatal cardiac adverse reactions occurred in patients with light chain (AL) amyloidosis who received DARZALEX FASPRO in combination with bortezomib, cyclophosphamide and dexamethasone [see Adverse Reactions (6.1) ].
Source: FDA drug label (Darzalex Faspro), Janssen Biotech, Inc., effective September 3, 2026 (SPL set 4bb241af-4299-4373-8762-2d6709515db0), via openFDA; the full label on DailyMed
What does the dexamethasone label say about daratumumab/hyaluronidase?
Dexamethasone's label (effective June 6, 2025) and its 3 other brand-application labels do not name daratumumab/hyaluronidase in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Dexamethasone Intensol), Hikma Pharmaceuticals USA, Inc., effective June 6, 2025 (SPL set b15200fb-1826-472b-a907-e677a272513b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Daratumumab/hyaluronidase | Dexamethasone | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Asthma, Eczema (atopic dermatitis), Leukemia, lymphoma and myeloma, Herpes and shingles, Crohn's disease and ulcerative colitis, Multiple sclerosis, Osteoarthritis, Rheumatoid arthritis, Psoriasis, Allergies, Anemia, Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.193 per tablet 4 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once