What the FDA labels say about taking them together
Dapsone and pyrimethamine
Dapsone's FDA label of July 20, 2026 names pyrimethamine in its drug interactions section; the pyrimethamine label PlainMeds reads does not name dapsone. The dapsone label: “Folic acid antagonists such as pyrimethamine may increase the likelihood of hematologic reactions.”
Check it at the source: the dapsone FDA label on DailyMed (effective July 20, 2026, Macleods Pharmaceuticals Limited); the pyrimethamine FDA label on DailyMed (effective December 7, 2023, TILDE Sciences LLC).
What does the dapsone label say about pyrimethamine?
Dapsone label, drug interactionsFolic acid antagonists such as pyrimethamine may increase the likelihood of hematologic reactions.
Dapsone label, warningsPatients on weekly pyrimethamine and dapsone have developed agranulocytosis during the second and third month of therapy.
Source: FDA drug label (Aczone, NDA207154), Almirall, LLC, effective October 23, 2025 (SPL set 22058b7d-a578-4eaa-a476-ac982337f02a), via openFDA
Source: FDA drug label (Dapsone), Macleods Pharmaceuticals Limited, effective July 20, 2026 (SPL set 839d7440-ba0e-4c56-b648-d374b155cf03), via openFDA; the full label on DailyMed
What does the pyrimethamine label say about dapsone?
Pyrimethamine's label (effective December 7, 2023) does not name dapsone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Daraprim), TILDE Sciences LLC, effective December 7, 2023 (SPL set f634f34b-0952-4dd3-9da3-f84b6ab823de), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dapsone | Pyrimethamine | |
|---|---|---|
| Labeled for | Acne | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.664 per gram 5% gel | $137.01 per tablet 25 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once