What the FDA labels say about taking them together
Daprodustat and gemfibrozil
Daprodustat's FDA label of August 30, 2023 names gemfibrozil in its contraindications section; the gemfibrozil labels PlainMeds reads (2) do not name daprodustat. The daprodustat label: “CONTRAINDICATIONS JESDUVROQ is contraindicated in patients: Receiving a strong CYP2C8 inhibitor such as gemfibrozil.”
Check it at the source: the daprodustat FDA label on DailyMed (effective August 30, 2023, GlaxoSmithKline LLC); the gemfibrozil FDA label on DailyMed (effective April 10, 2026, Northstar RxLLC).
What does the daprodustat label say about gemfibrozil?
Daprodustat label, contraindicationsCONTRAINDICATIONS JESDUVROQ is contraindicated in patients: Receiving a strong CYP2C8 inhibitor such as gemfibrozil [see Drug Interactions ( 7.1 ), Clinical Pharmacology ( 12.3 )].
Daprodustat label, drug interactionsConcomitant administration of strong CYP2C8 inhibitors (e.g., gemfibrozil) with JESDUVROQ is contraindicated due to a marked increase in daprodustat exposure [see Contraindications ( 4 ), Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Jesduvroq), GlaxoSmithKline LLC, effective August 30, 2023 (SPL set d82aa06e-5a33-4844-99b7-4701313455a4), via openFDA; the full label on DailyMed
What does the gemfibrozil label say about daprodustat?
Gemfibrozil's label (effective April 10, 2026) and its 1 other brand-application label do not name daprodustat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Gemfibrozil), Northstar RxLLC, effective April 10, 2026 (SPL set 75cac02c-56e3-4dfe-b1e2-4ce166b28833), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Daprodustat | Gemfibrozil | |
|---|---|---|
| Labeled for | Anemia | High cholesterol, Heart attack and coronary artery disease |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.104 per tablet 600 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once