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What the FDA labels say about taking them together

Dantrolene and sevoflurane

Sevoflurane's FDA label of February 12, 2025 names dantrolene in its warnings section; the dantrolene labels PlainMeds reads (3) do not name sevoflurane.

Check it at the source: the dantrolene FDA label on DailyMed (effective August 21, 2026, Par Health USA, LLC); the sevoflurane FDA label on DailyMed (effective February 12, 2025, AbbVie Inc.).

What does the dantrolene label say about sevoflurane?

Dantrolene's label (effective August 21, 2026) and its 2 other brand-application labels do not name sevoflurane in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (dantrolene sodium), Par Health USA, LLC, effective August 21, 2026 (SPL set 11689f56-15e0-4350-b53f-ae96e5994fea), via openFDA; the full label on DailyMed

What does the sevoflurane label say about dantrolene?

Sevoflurane label, warnings

If malignant hyperthermia is suspected, discontinue all triggering agents (i.e., volatile anesthetic agents and succinylcholine), administer intravenous dantrolene sodium, and initiate supportive therapies.

Source: FDA drug label (Ultane), AbbVie Inc., effective February 12, 2025 (SPL set c9aa6489-5a36-44ed-9512-b996833d82f7), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

10Dantrolene generic labelers
9Sevoflurane generic labelers
DantroleneSevoflurane
Labeled forMuscle spasms and spasticityn/a
Boxed warningYesNo
Pharmacy cost (NADAC)$0.409 per capsule 25 mg capsulen/a
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?