What the FDA labels say about taking them together
Dalfampridine and trilaciclib
Trilaciclib's FDA label of August 31, 2025 names dalfampridine in its drug interactions section; the dalfampridine label PlainMeds reads does not name trilaciclib. The trilaciclib label: “The potential benefits of taking COSELA concurrently with dalfampridine should be considered against the risk of seizures in these patients.; …”
Check it at the source: the dalfampridine FDA label on DailyMed (effective January 16, 2026, Merz Pharmaceuticals, LLC); the trilaciclib FDA label on DailyMed (effective August 31, 2025, Pharmacosmos Therapeutics Inc.).
What does the dalfampridine label say about trilaciclib?
Dalfampridine's label (effective January 16, 2026) does not name trilaciclib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (AMPYRA), Merz Pharmaceuticals, LLC, effective January 16, 2026 (SPL set 550eb76a-e4a6-4fa1-ad65-c0fd8b0ce783), via openFDA; the full label on DailyMed
What does the trilaciclib label say about dalfampridine?
Trilaciclib label, drug interactionsDrugs: Dalfampridine; Recommendations: The potential benefits of taking COSELA concurrently with dalfampridine should be considered against the risk of seizures in these patients.; Comments: Increased dalfampridine blood levels may occur in patients who are also receiving COSELA. Elevated levels of dalfampridine increase the risk of seizure.
Source: FDA drug label (COSELA), Pharmacosmos Therapeutics Inc., effective August 31, 2025 (SPL set b3179c19-78f3-4bf1-b73e-7f7638522ab1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dalfampridine | Trilaciclib | |
|---|---|---|
| Labeled for | Multiple sclerosis | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.399 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once