What the FDA labels say about taking them together
Cytarabine and procarbazine
Cytarabine's FDA label of April 7, 2025 names procarbazine in its drug interactions section; the procarbazine label PlainMeds reads does not name cytarabine. The cytarabine label: “… cyclophosphamide, vincristine and prednisone with or without cytarabine injection or procarbazine.”
Check it at the source: the cytarabine FDA label on DailyMed (effective April 7, 2025, Hospira, Inc.); the procarbazine FDA label on DailyMed (effective September 16, 2024, Leadiant Biosciences, Inc.).
What does the cytarabine label say about procarbazine?
Cytarabine label, drug interactionsDrug Interactions Reversible decreases in steady-state plasma digoxin concentrations and renal glycoside excretion were observed in patients receiving beta-acetyldigoxin and chemotherapy regimens containing cyclophosphamide, vincristine and prednisone with or without cytarabine injection or procarbazine.
Source: FDA drug label (Cytarabine), Hospira, Inc., effective April 7, 2025 (SPL set e3a8c0e9-19ed-49b7-8464-11e8806f47fd), via openFDA; the full label on DailyMed
What does the procarbazine label say about cytarabine?
Procarbazine's label (effective September 16, 2024) does not name cytarabine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Matulane), Leadiant Biosciences, Inc., effective September 16, 2024 (SPL set 1aa75a3a-18c9-49e1-91a6-293d0b7da756), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cytarabine | Procarbazine | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once