What the FDA labels say about taking them together
Cyclosporine and sulfamethoxazole/trimethoprim
Sulfamethoxazole/trimethoprim's FDA label of December 30, 2024 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name sulfamethoxazole/trimethoprim. The sulfamethoxazole/trimethoprim label: “Cyclosporine Avoid concurrent use There have been reports of marked but reversible nephrotoxicity with coadministration of BACTRIM and cyclosporine in renal transplant recipients.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the sulfamethoxazole/trimethoprim FDA label on DailyMed (effective December 30, 2024, Sun Pharmaceutical Industries, Inc).
What does the cyclosporine label say about sulfamethoxazole/trimethoprim?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name sulfamethoxazole/trimethoprim in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the sulfamethoxazole/trimethoprim label say about cyclosporine?
Sulfamethoxazole/trimethoprim label, drug interactionsCyclosporine Avoid concurrent use There have been reports of marked but reversible nephrotoxicity with coadministration of BACTRIM and cyclosporine in renal transplant recipients.
Sulfatrim label (Preferred Pharmaceuticals, Inc., September 2, 2026), drug interactionsThere have been reports of marked but reversible nephrotoxicity with coadministration of sulfamethoxazole and trimethoprim and cyclosporine in renal transplant recipients.
Source: FDA drug label (Sulfatrim, NDA018615), Preferred Pharmaceuticals, Inc., effective September 2, 2026 (SPL set cd4932ce-0856-4e99-8baf-70afce1d7ffd), via openFDA
Source: FDA drug label (Bactrim), Sun Pharmaceutical Industries, Inc, effective December 30, 2024 (SPL set f59d0c04-9c66-4d53-a0e1-cb55570deb62), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Sulfamethoxazole/trimethoprim | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Bacterial infections, Urinary tract infections, Diarrhea |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.0448 per tablet Sulfamethoxazole-tmp ds tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once