What the FDA labels say about taking them together
Cyclosporine and siltuximab
Siltuximab's FDA label of August 27, 2024 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name siltuximab. The siltuximab label: “Upon initiation or discontinuation of SYLVANT, in patients being treated with CYP450 substrates with a narrow therapeutic index, perform therapeutic monitoring of effect (e.g., warfarin) or drug concentration as needed …”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the siltuximab FDA label on DailyMed (effective August 27, 2024).
What does the cyclosporine label say about siltuximab?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name siltuximab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the siltuximab label say about cyclosporine?
Siltuximab label, drug interactionsUpon initiation or discontinuation of SYLVANT, in patients being treated with CYP450 substrates with a narrow therapeutic index, perform therapeutic monitoring of effect (e.g., warfarin) or drug concentration (e.g., cyclosporine or theophylline) as needed and adjust dose.
Source: FDA drug label (Sylvant), Recordati Rare Diseases, Inc., effective August 27, 2024 (SPL set 8d663642-f52e-49c0-a023-2da083fdfc0b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Siltuximab | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once