What the FDA labels say about taking them together
Cyclosporine and sevelamer
Sevelamer's FDA label of November 25, 2025 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name sevelamer.
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the sevelamer FDA label on DailyMed (effective November 25, 2025, Sanofi-Aventis U.S. LLC).
What does the cyclosporine label say about sevelamer?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name sevelamer in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the sevelamer label say about cyclosporine?
Sevelamer label, drug interactionsFor oral medication where a reduction in the bioavailability of that medication would have a clinically significant effect on its safety or efficacy (e.g., cyclosporine, tacrolimus, levothyroxine), consider separation of the timing of the administration of the two drugs [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Sevelamer Carbonate), Sanofi-Aventis U.S. LLC, effective November 25, 2025 (SPL set 3abc32fe-1bfc-4759-8f7c-36095e221b06), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Sevelamer | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.214 per tablet 800 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once