What the FDA labels say about taking them together
Cyclosporine and seladelpar lysine
Seladelpar lysine's FDA label of February 3, 2026 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name seladelpar lysine. The seladelpar lysine label: “Concomitant Drug or Class: Dual or Multiple Clinical Inhibitors of Drug Transporters OATP1B1, OATP1B3, and BCRP (e.g, cyclosporine); Potential Effect on Seladelpar Exposure ↑ = Increase, ↓ = Decrease.: ↑ seladelpar; …”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the seladelpar lysine FDA label on DailyMed (effective February 3, 2026, Gilead Sciences, Inc).
What does the cyclosporine label say about seladelpar lysine?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name seladelpar lysine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the seladelpar lysine label say about cyclosporine?
Seladelpar lysine label, drug interactionsConcomitant Drug or Class: Dual or Multiple Clinical Inhibitors of Drug Transporters OATP1B1, OATP1B3, and BCRP (e.g, cyclosporine); Potential Effect on Seladelpar Exposure ↑ = Increase, ↓ = Decrease.: ↑ seladelpar; Clinical Intervention: Monitor patients for adverse effects during concomitant use of LIVDELZI with dual or multiple clinical inhibitors of drug transporters OATP1B1, OATP1B3, and BCRP.
Source: FDA drug label (Livdelzi), Gilead Sciences, Inc, effective February 3, 2026 (SPL set 89f79d98-135c-40b2-a585-6996c04e599c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Seladelpar lysine | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once