What the FDA labels say about taking them together
Cyclosporine and prednisolone
Cyclosporine's FDA label of August 10, 2026 names prednisolone in its drug interactions section, and prednisolone's label names cyclosporine too. The prednisolone label: “Cyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the prednisolone FDA label on DailyMed (effective June 25, 2026, PAI Holdings, LLC dba PAI Pharma).
What does the cyclosporine label say about prednisolone?
Cyclosporine label, drug interactionsCyclosporine may reduce the clearance of digoxin, colchicine, prednisolone, HMG-CoA reductase inhibitors (statins), aliskiren, bosentan, dabigatran, repaglinide, NSAIDs, sirolimus, etoposide, and other drugs.
Source: FDA drug label (Sandimmune, NDA050573), Novartis Pharmaceuticals Corporation, effective July 10, 2026 (SPL set 5e5926a7-1de0-4b54-a5c0-286b6200ff82), via openFDA
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the prednisolone label say about cyclosporine?
Orapred Odt label (Advanz Pharma (US) Corp., June 3, 2025), drug interactionsCyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently.
Source: FDA drug label (Orapred Odt, NDA021959), Advanz Pharma (US) Corp., effective June 3, 2025 (SPL set 1e379543-c4cf-4e72-953b-db15b7f0c2a1), via openFDA
Source: FDA drug label (PrednisoLONE Sodium Phosphate), PAI Holdings, LLC dba PAI Pharma, effective June 25, 2026 (SPL set d1f937e7-fed5-4079-bd52-5d930b34ae9f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Prednisolone | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Anemia, Leukemia, lymphoma and myeloma, Multiple sclerosis, Osteoarthritis, Asthma, Allergies, Herpes and shingles, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis), Organ transplant rejection |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $4.72 per mL 1% eye drop |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once