What the FDA labels say about taking them together
Cyclosporine and paltusotine
Paltusotine's FDA label of September 16, 2025 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name paltusotine. The paltusotine label: “May require PALSONIFY dosage increase Cyclosporine: may decrease cyclosporine exposure.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the paltusotine FDA label on DailyMed (effective September 16, 2025, Crinetics Pharmaceuticals, Inc.).
What does the cyclosporine label say about paltusotine?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name paltusotine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the paltusotine label say about cyclosporine?
Paltusotine label, drug interactionsMay require PALSONIFY dosage increase ( 2.3 , 7.1 ) Cyclosporine: may decrease cyclosporine exposure.
Source: FDA drug label (PALSONIFY), Crinetics Pharmaceuticals, Inc., effective September 16, 2025 (SPL set 8a6d2ce0-a621-4ee7-983c-977cd948ff4d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Paltusotine | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once