What the FDA labels say about taking them together
Cyclosporine and orlistat
Cyclosporine's FDA label of August 10, 2026 names orlistat in its drug interactions section, and orlistat's label names cyclosporine too. The cyclosporine label: “Compounds that decrease cyclosporine absorption, such as orlistat, should be avoided.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the orlistat FDA label on DailyMed (effective March 18, 2026, Haleon US Holdings LLC).
What does the cyclosporine label say about orlistat?
Cyclosporine label, drug interactionsCompounds that decrease cyclosporine absorption, such as orlistat, should be avoided.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the orlistat label say about cyclosporine?
Orlistat label, drug interactions (prescription label)DRUG INTERACTIONS Cyclosporine: Reduction in cyclosporine plasma levels was observed when XENICAL was coadministered with cyclosporine. ( 7.1 ) Fat-soluble Vitamin Supplements and Analogues:
Orlistat label, warnings and precautions (prescription label)Interactions and Decreased Vitamin Absorption XENICAL may interact with concomitant drugs including cyclosporine, levothyroxine, warfarin, amiodarone, antiepileptic drugs, and antiretroviral drugs [see Drug Interactions (7) ].
Orlistat label, warningsAllergy alert: do not use if you are allergic to any of the ingredients in orlistat capsules Do not use if you are taking cyclosporine if you have been diagnosed with problems absorbing food if you are not overweight Ask a doctor before use if you have ever had gallbladder problems kidney disease or kidney stones pancreatitis Ask a doctor or pharmacist before use if you are taking any of the following prescription medications.
Source: FDA drug label (ALLI), Haleon US Holdings LLC, effective March 18, 2026 (SPL set a2d3bd73-f3af-4ea5-a57c-66b0004cfe4f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Orlistat | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Weight management |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $7.00 per capsule 120 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once