What the FDA labels say about taking them together
Cyclosporine and omeprazole
Omeprazole's FDA label of April 22, 2024 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name omeprazole.
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).
What does the cyclosporine label say about omeprazole?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name omeprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the omeprazole label say about cyclosporine?
Omeprazole label, drug interactionsClinical Impact: There have been clinical reports of interactions with other drugs metabolized via the cytochrome P450 system (…). Intervention: Monitor patients to determine if it is necessary to adjust the dosage of these other drugs when taken concomitantly with omeprazole. Clinically Relevant Interactions Affecting Omeprazole When Co-Administered with Other Drugs CYP2C19 or CYP3A4 Inducers
Source: FDA drug label (Prilosec, NDA022056), Covis Pharma US, Inc, effective March 19, 2024 (SPL set b6761f84-53ac-4745-a8c8-1e5427d7e179), via openFDA
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Omeprazole | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.0295 per capsule 20 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once