What the FDA labels say about taking them together
Cyclosporine and metreleptin
Metreleptin's FDA label of March 25, 2024 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name metreleptin. The metreleptin label: “Upon initiation or discontinuation of MYALEPT, in patients being treated with these types of agents, therapeutic monitoring of effect (e.g., warfarin) or drug concentration should be performed and the individual dose of …”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the metreleptin FDA label on DailyMed (effective March 25, 2024, Chiesi USA, Inc.).
What does the cyclosporine label say about metreleptin?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name metreleptin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the metreleptin label say about cyclosporine?
Metreleptin label, drug interactionsUpon initiation or discontinuation of MYALEPT, in patients being treated with these types of agents, therapeutic monitoring of effect (e.g., warfarin) or drug concentration (e.g., cyclosporine or theophylline) should be performed and the individual dose of the agent adjusted as needed.
Source: FDA drug label (Myalept), Chiesi USA, Inc., effective March 25, 2024 (SPL set d3b50bbd-140b-425c-b5ec-d4682aad62bc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Metreleptin | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once