What the FDA labels say about taking them together
Cyclosporine and melphalan
Cyclosporine's FDA label of August 10, 2026 names melphalan in its drug interactions section, and melphalan's label names cyclosporine too. The melphalan label: “Concomitant use with cyclosporine may increase the risk of developing severe renal failure.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the melphalan FDA label on DailyMed (effective July 7, 2026, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.).
What does the cyclosporine label say about melphalan?
Cyclosporine label, drug interactionsciprofloxacin; melphalan; amphotericin B; azapropazon; cimetidine; tacrolimus; fibric acid derivatives (e.g., bezafibrate, fenofibrate)
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the melphalan label say about cyclosporine?
Melphalan label, drug interactionsDrug Interactions The development of severe renal failure has been reported in patients treated with a single dose of IV melphalan followed by standard oral doses of cyclosporine.
Ivra label (Apotex Corp, September 4, 2025), drug interactionsConcomitant use with cyclosporine may increase the risk of developing severe renal failure [see Clinical Pharmacology ( 12.3 ) ].
Source: FDA drug label (Ivra, NDA217110), Apotex Corp, effective September 4, 2025 (SPL set c23e868a-dc62-2181-5099-76c9226602b2), via openFDA
Source: FDA drug label (Evomela, NDA207155), Acrotech Biopharma Inc, effective June 9, 2023 (SPL set 69f55869-dc11-408e-8fc7-47634269a52c), via openFDA
Source: FDA drug label (Melphalan hydrochloride), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective July 7, 2026 (SPL set 2c18beeb-7bd4-4591-94cb-9d7156c1b8e0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Melphalan | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Leukemia, lymphoma and myeloma |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once