What the FDA labels say about taking them together
Cyclosporine and mannitol
Mannitol's FDA label of August 26, 2025 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name mannitol. The mannitol label: “Concomitant administration of nephrotoxic drugs increases the risk of renal failure following administration of mannitol.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the mannitol FDA label on DailyMed (effective August 26, 2025, Baxter Healthcare Company).
What does the cyclosporine label say about mannitol?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name mannitol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the mannitol label say about cyclosporine?
Mannitol label, drug interactionsConcomitant administration of nephrotoxic drugs (e.g., cyclosporine, aminoglycosides) increases the risk of renal failure following administration of mannitol.
Source: FDA drug label (Mannitol, NDA019603), ICU Medical Inc., effective October 24, 2025 (SPL set ba7bf864-8a4d-4262-8fd1-00174fa2f9d1), via openFDA
Source: FDA drug label (Osmitrol), Baxter Healthcare Company, effective August 26, 2025 (SPL set 0d914965-7001-45cb-ba51-d7c5964b05bc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Mannitol | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Edema (fluid retention) |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once