What the FDA labels say about taking them together
Cyclosporine and ketorolac
Ketorolac's FDA label (Sprix) of December 5, 2024 names cyclosporine in its drug interactions section; cyclosporine's label does not name ketorolac itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The ketorolac label: “Concomitant use of SPRIX and cyclosporine may increase cyclosporine’s nephrotoxicity.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the ketorolac FDA label on DailyMed (effective August 31, 2023, Fresenius Kabi USA, LLC).
What does the cyclosporine label say about ketorolac?
Cyclosporine's label does not name ketorolac itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Cyclosporine label, drug interactionsIn addition, concomitant use of NSAIDs with cyclosporine, particularly in the setting of dehydration, may potentiate renal dysfunction.
Cyclosporine label, drug interactionsCyclosporine may reduce the clearance of digoxin, colchicine, prednisolone, HMG-CoA reductase inhibitors (statins), aliskiren, bosentan, dabigatran, repaglinide, NSAIDs, sirolimus, etoposide, and other drugs.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the ketorolac label say about cyclosporine?
Sprix label (Zyla Life Sciences US LLC, December 5, 2024), drug interactionsClinical Impact: Concomitant use of SPRIX and cyclosporine may increase cyclosporine’s nephrotoxicity. Intervention: During concomitant use of SPRIX and cyclosporine, monitor patients for signs of worsening renal function. NSAIDs and Salicylates
Source: FDA drug label (Sprix, NDA022382), Zyla Life Sciences US LLC, effective December 5, 2024 (SPL set 97005a1c-167e-4676-bae7-e49b38c36f9e), via openFDA
Source: FDA drug label (Ketorolac Tromethamine), Fresenius Kabi USA, LLC, effective August 31, 2023 (SPL set 3d88cbe6-5230-47aa-80af-0c41283d1f00), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Ketorolac | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $1.02 per mL 30 mg/mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once