What the FDA labels say about taking them together
Cyclosporine and ivacaftor
Ivacaftor's FDA label of March 23, 2026 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name ivacaftor. The ivacaftor label: “Therefore, caution and appropriate monitoring are recommended when co-administering KALYDECO with sensitive CYP3A and/or P-gp substrates, such as digoxin, cyclosporine, and tacrolimus [ see Clinical Pharmacology ].”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the ivacaftor FDA label on DailyMed (effective March 23, 2026, Vertex Pharmaceuticals Incorporated).
What does the cyclosporine label say about ivacaftor?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name ivacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the ivacaftor label say about cyclosporine?
Ivacaftor label, drug interactionsTherefore, caution and appropriate monitoring are recommended when co-administering KALYDECO with sensitive CYP3A and/or P-gp substrates, such as digoxin, cyclosporine, and tacrolimus [ see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Kalydeco), Vertex Pharmaceuticals Incorporated, effective March 23, 2026 (SPL set 0ab0c9f8-3eee-4e0f-9f3f-c1e16aaffe25), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Ivacaftor | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once