What the FDA labels say about taking them together
Cyclosporine and imatinib
Cyclosporine's FDA label of August 10, 2026 names imatinib in its drug interactions section; the imatinib labels PlainMeds reads (3) do not name cyclosporine. The cyclosporine label: “… Bromocriptine voriconazole quinupristin/ dalfopristin colchicine danazol imatinib metoclopramide nefazodone oral contraceptives HIV Protease Inhibitors The HIV protease inhibitors are known to inhibit cytochrome P-450 …”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the imatinib FDA label on DailyMed (effective September 8, 2026, Apotex Corp).
What does the cyclosporine label say about imatinib?
Cyclosporine label, drug interactionsDrugs That Increase Cyclosporine Concentrations Calcium Channel Blockers Antifungals Antibiotics Glucocorticoids Other Drugs diltiazem fluconazole azithromycin methylprednisolone Allopurinol nicardipine itraconazole clarithromycin Amiodarone verapamil ketoconazole erythromycin Bromocriptine voriconazole quinupristin/ dalfopristin colchicine danazol imatinib metoclopramide nefazodone oral contraceptives HIV Protease Inhibitors The HIV protease inhibitors (e.g., indinavir, nelfinavir, ritonavir, and saquinavir) are known to inhibit cytochrome P-450 3A and thus could potentially increase the concentrations of cyclosporine, however no formal studies of the interaction are available.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the imatinib label say about cyclosporine?
Imatinib's label (effective September 8, 2026) and its 2 other brand-application labels do not name cyclosporine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Imatinib Mesylate), Apotex Corp, effective September 8, 2026 (SPL set 0291eca5-7a1d-4a79-30be-252224d96509), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Imatinib | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Leukemia, lymphoma and myeloma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.624 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once