What the FDA labels say about taking them together
Cyclosporine and ibuprofen
Ibuprofen's FDA label (Caldolor) of January 29, 2026 names cyclosporine in its drug interactions section; cyclosporine's label does not name ibuprofen itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The ibuprofen label: “Concomitant use of CALDOLOR and cyclosporine may increase cyclosporine's nephrotoxicity.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the ibuprofen FDA label on DailyMed (effective January 1, 2026, Savings Distributors LLC).
What does the cyclosporine label say about ibuprofen?
Cyclosporine's label does not name ibuprofen itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Cyclosporine label, drug interactionsIn addition, concomitant use of NSAIDs with cyclosporine, particularly in the setting of dehydration, may potentiate renal dysfunction.
Cyclosporine label, drug interactionsCyclosporine may reduce the clearance of digoxin, colchicine, prednisolone, HMG-CoA reductase inhibitors (statins), aliskiren, bosentan, dabigatran, repaglinide, NSAIDs, sirolimus, etoposide, and other drugs.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the ibuprofen label say about cyclosporine?
Caldolor label (Cumberland Pharmaceuticals Inc., January 29, 2026), drug interactionsClinical Impact: Concomitant use of CALDOLOR and cyclosporine may increase cyclosporine's nephrotoxicity. Intervention: During concomitant use of CALDOLOR and cyclosporine, monitor patients for signs of worsening renal function. NSAIDs and Salicylates
Source: FDA drug label (Caldolor, NDA022348), Cumberland Pharmaceuticals Inc., effective January 29, 2026 (SPL set 1eaa7790-f1a1-4f51-b10a-cbbaf033f684), via openFDA
Source: FDA drug label (Motrin IB), NDA019012 (Kenvue Brands), as published by Savings Distributors LLC, effective January 1, 2026 (SPL set 56846774-8413-c306-e063-6394a90a2be8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Ibuprofen | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Fever, Osteoarthritis, Rheumatoid arthritis, Pain, Cough and cold |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.0573 per tablet 800 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once