What the FDA labels say about taking them together
Cyclosporine and hydrocortisone
Hydrocortisone's FDA label (Solu-Cortef) of August 27, 2026 names cyclosporine in its drug interactions section; cyclosporine's label does not name hydrocortisone itself but warns about its class (Corticosteroids). The hydrocortisone label: “Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently. Convulsions have been reported with concurrent use.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the hydrocortisone FDA label on DailyMed (effective August 19, 2026).
What does the cyclosporine label say about hydrocortisone?
Cyclosporine's label does not name hydrocortisone itself; it warns about its class (Corticosteroids):
Cyclosporine label, warningsPredisposing factors, such as hypertension, hypomagnesemia, hypocholesterolemia, high-dose corticosteroids, high cyclosporine blood concentrations, and graft-versus-host disease, have been noted in many but not all of the reported cases.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the hydrocortisone label say about cyclosporine?
Solu-Cortef label (Pharmacia & Upjohn Company LLC, August 27, 2026), drug interactionsCyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently.
Alkindi Sprinkle label (Eton Pharmaceuticals, Inc., April 21, 2026), drug interactionsClinical Impact: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently. Convulsions have been reported with concurrent use. Intervention: Monitor patients receiving ALKINDI SPRINKLE and concomitant cyclosporine. Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Source: FDA drug label (Solu-Cortef, NDA009866), Pharmacia & Upjohn Company LLC, effective August 27, 2026 (SPL set 65eefd58-b166-4d71-ade6-45c8fdf86922), via openFDA
Source: FDA drug label (Alkindi Sprinkle, NDA213876), Eton Pharmaceuticals, Inc., effective April 21, 2026 (SPL set 26c13a5f-7119-4c6a-bf10-fda4e07d7682), via openFDA
Source: FDA drug label (hydrocortisone 1), Kroger Company, effective August 19, 2026 (SPL set f05edff2-2dc5-427c-b52c-518e0aaef4e0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Hydrocortisone | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis) |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.0613 per gram 1% cream |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once