What the FDA labels say about taking them together
Cyclosporine and hydrochlorothiazide/valsartan
Hydrochlorothiazide/valsartan's FDA label of February 13, 2026 names cyclosporine in its drug interactions section; cyclosporine's label does not name hydrochlorothiazide/valsartan itself but warns about its class (ARBs (angiotensin II receptor blockers), Thiazide diuretics). The hydrochlorothiazide/valsartan label: “Cyclosporine: Concomitant treatment with cyclosporine may increase the risk of hyperuricemia and gout-type complications.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the hydrochlorothiazide/valsartan FDA label on DailyMed (effective February 13, 2026, Novartis Pharmaceuticals Corporation).
What does the cyclosporine label say about hydrochlorothiazide/valsartan?
Cyclosporine's label does not name hydrochlorothiazide/valsartan itself; it warns about its class (ARBs (angiotensin II receptor blockers), Thiazide diuretics):
Cyclosporine label, drug interactionsCaution is also required when cyclosporine is coadministered with potassium sparing drugs (e.g., angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists), potassium-containing drugs as well as in patients on a potassium rich diet.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the hydrochlorothiazide/valsartan label say about cyclosporine?
Hydrochlorothiazide/valsartan label, drug interactionsCyclosporine: Concomitant treatment with cyclosporine may increase the risk of hyperuricemia and gout-type complications.
Source: FDA drug label (Diovan HCT), Novartis Pharmaceuticals Corporation, effective February 13, 2026 (SPL set d76a0419-05ee-437e-884c-65807aea9569), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Hydrochlorothiazide/valsartan | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | High blood pressure |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.101 per tablet 160-12.5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once