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What the FDA labels say about taking them together

Cyclosporine and fosamprenavir

Fosamprenavir's FDA label of September 15, 2023 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name fosamprenavir. The fosamprenavir label: “Therapeutic concentration monitoring is recommended for immunosuppressant agents.”

Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.).

What does the cyclosporine label say about fosamprenavir?

Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed

What does the fosamprenavir label say about cyclosporine?

Fosamprenavir label, drug interactions

Concomitant Drug Class/Drug Name: Immunosuppressants: Cyclosporine, tacrolimus, sirolimus; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Immunosuppressants; Clinical Comment: Therapeutic concentration monitoring is recommended for immunosuppressant agents.

Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

14Cyclosporine generic labelers
2Fosamprenavir generic labelers
CyclosporineFosamprenavir
Labeled forOrgan transplant rejection, Rheumatoid arthritisHIV
Boxed warningYesNo
Pharmacy cost (NADAC)$1.04 per unit 0.05% eye emulsionn/a
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?