What the FDA labels say about taking them together
Cyclosporine and fenoprofen
Fenoprofen's FDA label of August 20, 2026 names cyclosporine in its drug interactions section; cyclosporine's label does not name fenoprofen itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The fenoprofen label: “Concomitant use of FENOPROFEN CALCIUM and cyclosporine may increase cyclosporine’s nephrotoxicity.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the fenoprofen FDA label on DailyMed (effective August 20, 2026, Misemer Pharmaceuticals, Inc.).
What does the cyclosporine label say about fenoprofen?
Cyclosporine's label does not name fenoprofen itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Cyclosporine label, drug interactionsIn addition, concomitant use of NSAIDs with cyclosporine, particularly in the setting of dehydration, may potentiate renal dysfunction.
Cyclosporine label, drug interactionsCyclosporine may reduce the clearance of digoxin, colchicine, prednisolone, HMG-CoA reductase inhibitors (statins), aliskiren, bosentan, dabigatran, repaglinide, NSAIDs, sirolimus, etoposide, and other drugs.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the fenoprofen label say about cyclosporine?
Fenoprofen label, drug interactionsClinical Impact: Concomitant use of FENOPROFEN CALCIUM and cyclosporine may increase cyclosporine’s nephrotoxicity. Intervention: During concomitant use of FENOPROFEN CALCIUM and cyclosporine, monitor patients for signs of worsening renal function. NSAIDs and Salicylates
Source: FDA drug label (Fenoprofen Calcium), Misemer Pharmaceuticals, Inc., effective August 20, 2026 (SPL set d33ad329-1ca6-ac2e-e053-2995a90a15c5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Fenoprofen | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Pain, Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once