What the FDA labels say about taking them together
Cyclosporine and etoposide
Cyclosporine's FDA label of August 10, 2026 names etoposide in its drug interactions section; the etoposide labels PlainMeds reads (3) do not name cyclosporine. The cyclosporine label: “Cyclosporine may reduce the clearance of digoxin, colchicine, prednisolone, HMG-CoA reductase inhibitors (statins), aliskiren, bosentan, dabigatran, repaglinide, NSAIDs, sirolimus, etoposide, and other drugs.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the etoposide FDA label on DailyMed (effective September 14, 2023, Hikma Pharmaceuticals USA Inc.).
What does the cyclosporine label say about etoposide?
Cyclosporine label, drug interactionsCyclosporine may reduce the clearance of digoxin, colchicine, prednisolone, HMG-CoA reductase inhibitors (statins), aliskiren, bosentan, dabigatran, repaglinide, NSAIDs, sirolimus, etoposide, and other drugs.
Source: FDA drug label (Sandimmune, NDA050573), Novartis Pharmaceuticals Corporation, effective July 10, 2026 (SPL set 5e5926a7-1de0-4b54-a5c0-286b6200ff82), via openFDA
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the etoposide label say about cyclosporine?
Etoposide's label (effective September 14, 2023) and its 2 other brand-application labels do not name cyclosporine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Etoposide), Hikma Pharmaceuticals USA Inc., effective September 14, 2023 (SPL set 6dfedeff-a807-4405-a482-2f7109ad31c9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Etoposide | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Lung cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once