What the FDA labels say about taking them together
Cyclosporine and ethinyl estradiol/ferrous fumarate/levonorgestrel
Ethinyl estradiol/ferrous fumarate/levonorgestrel's FDA label of October 18, 2024 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name ethinyl estradiol/ferrous fumarate/levonorgestrel. The ethinyl estradiol/ferrous fumarate/levonorgestrel label: “Contraceptives on Other Drugs Combined oral contraceptives containing EE may inhibit the metabolism of other compounds and increase their plasma concentrations.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the ethinyl estradiol/ferrous fumarate/levonorgestrel FDA label on DailyMed (effective October 18, 2024, Xiromed, LLC).
What does the cyclosporine label say about ethinyl estradiol/ferrous fumarate/levonorgestrel?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name ethinyl estradiol/ferrous fumarate/levonorgestrel in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/ferrous fumarate/levonorgestrel label say about cyclosporine?
Ethinyl estradiol/ferrous fumarate/levonorgestrel label, drug interactionsContraceptives on Other Drugs Combined oral contraceptives containing EE may inhibit the metabolism of other compounds (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole) and increase their plasma concentrations.
Source: FDA drug label (Joyeaux), Xiromed, LLC, effective October 18, 2024 (SPL set 655b2c93-cfae-d44f-c128-c816bbd88e45), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Ethinyl estradiol/ferrous fumarate/levonorgestrel | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Birth control |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $3.45 per tablet 28 tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once