What the FDA labels say about taking them together
Cyclosporine and efavirenz
Efavirenz's FDA label of March 31, 2024 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name efavirenz. The efavirenz label: “Dose adjustments of the immunosuppressant may be required. Close monitoring of immunosuppressant concentrations for at least 2 weeks is recommended when starting or stopping treatment with efavirenz.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the efavirenz FDA label on DailyMed (effective March 31, 2024, Cipla USA Inc.).
What does the cyclosporine label say about efavirenz?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name efavirenz in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the efavirenz label say about cyclosporine?
Efavirenz label, drug interactionsConcomitant Drug Class/Drug Name: Immunosuppressants: Cyclosporine, tacrolimus, sirolimus and others metabolized by CYP3A; Effect: ↓ immunosuppressant; Clinical Comment: Dose adjustments of the immunosuppressant may be required. Close monitoring of immunosuppressant concentrations for at least 2 weeks (until stable concentrations are reached) is recommended when starting or stopping treatment with efavirenz.
Source: FDA drug label (Efavirenz), Cipla USA Inc., effective March 31, 2024 (SPL set 92603fa5-7a2c-4bfb-9a70-aadb4fba952c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Efavirenz | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $1.28 per tablet 600 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once