What the FDA labels say about taking them together
Cyclosporine and diclofenac
Cyclosporine's FDA label of August 10, 2026 names diclofenac in its drug interactions section, and diclofenac's label names cyclosporine too. The diclofenac label: “Concomitant use of LICART and cyclosporine may increase cyclosporine's nephrotoxicity.”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the diclofenac FDA label on DailyMed (effective February 11, 2025, Haleon US Holdings LLC).
What does the cyclosporine label say about diclofenac?
Cyclosporine label, drug interactionstobramycin; diclofenac
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the diclofenac label say about cyclosporine?
Diclofenac label, drug interactions (prescription label)Cyclosporine Diclofenac, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs.
Licart label (IBSA Pharma Inc., April 2, 2026), drug interactionsClinical Impact: Concomitant use of LICART and cyclosporine may increase cyclosporine's nephrotoxicity. Intervention: During concomitant use of LICART and cyclosporine, monitor patients for signs of worsening renal function. NSAIDs and Salicylates
Source: FDA drug label (Licart, NDA206976), IBSA Pharma Inc., effective April 2, 2026 (SPL set 851c8b39-6056-4bbc-812e-b9b13977c1ac), via openFDA
Source: FDA drug label (Flector, NDA021234), IBSA Pharma Inc., effective October 21, 2025 (SPL set 1f19a016-c4fc-43c5-9990-e5f2e2776a82), via openFDA
Source: FDA drug label (Zipsor, NDA022202), Assertio Specialty Pharmaceuticals LLC, effective March 1, 2026 (SPL set ed2a8868-78eb-47b8-8f46-0f70e2891e07), via openFDA
Source: FDA drug label (Voltaren Arthritis Pain), Haleon US Holdings LLC, effective February 11, 2025 (SPL set 30a94282-0892-442a-aa10-6525cbd4fe88), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Diclofenac | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Pain, Osteoarthritis, Rheumatoid arthritis, Migraine |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.0619 per tablet 75 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once