What the FDA labels say about taking them together
Cyclosporine and dibasic/monobasic
Dibasic/monobasic's FDA label of February 28, 2025 names cyclosporine in its drug interactions section; cyclosporine's label does not name dibasic/monobasic itself but warns about its class (potassium salts). The dibasic/monobasic label: “Products that Increase Serum Potassium Administration of Potassium Phosphates Injection to patients treated concurrently or recently with products that increase serum potassium increases the risk of severe and …”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the dibasic/monobasic FDA label on DailyMed (effective February 28, 2025, Fresenius Kabi USA, LLC).
What does the cyclosporine label say about dibasic/monobasic?
Cyclosporine's label does not name dibasic/monobasic itself; it warns about its class (potassium salts):
Cyclosporine label, drug interactionsCaution is also required when cyclosporine is coadministered with potassium sparing drugs (e.g., angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists), potassium-containing drugs as well as in patients on a potassium rich diet.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the dibasic/monobasic label say about cyclosporine?
Dibasic/monobasic label, drug interactionsProducts that Increase Serum Potassium Administration of Potassium Phosphates Injection to patients treated concurrently or recently with products that increase serum potassium (e.g., potassium- sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, digoxin, or the immunosuppressants tacrolimus and cyclosporine) increases the risk of severe and potentially fatal hyperkalemia, in particular in the presence of other risk factors for hyperkalemia [see Warnings and Precautions ( 5.3 )].
Source: FDA drug label (Potassium Phosphates), Fresenius Kabi USA, LLC, effective February 28, 2025 (SPL set 475f5cd7-45bd-412a-b419-9962585d6cda), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Dibasic/monobasic | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once