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What the FDA labels say about taking them together

Cyclosporine and daraxonrasib

Daraxonrasib's FDA label of August 27, 2026 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name daraxonrasib. The daraxonrasib label: “Cyclosporine A Prevention or Management Avoid concomitant use of RASONQUE with systemic cyclosporine A or its derivatives.”

Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the daraxonrasib FDA label on DailyMed (effective August 27, 2026, Revolution Medicines, Inc.).

What does the cyclosporine label say about daraxonrasib?

Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name daraxonrasib in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed

What does the daraxonrasib label say about cyclosporine?

Daraxonrasib label, drug interactions

Cyclosporine A Prevention or Management Avoid concomitant use of RASONQUE with systemic cyclosporine A or its derivatives.

Source: FDA drug label (RASONQUE), Revolution Medicines, Inc., effective August 27, 2026 (SPL set 13a65923-d072-4dac-8620-8eabbf8c3641), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

14Cyclosporine generic labelers
0Daraxonrasib generic labelers
CyclosporineDaraxonrasib
Labeled forOrgan transplant rejection, Rheumatoid arthritisn/a
Boxed warningYesNo
Pharmacy cost (NADAC)$1.04 per unit 0.05% eye emulsionn/a
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?