What the FDA labels say about taking them together
Cyclophosphamide and palonosetron
Palonosetron's FDA label (Palonosetron Hydrochloride) of January 13, 2022 names cyclophosphamide in its drug interactions section; the cyclophosphamide labels PlainMeds reads (4) do not name palonosetron.
Check it at the source: the cyclophosphamide FDA label on DailyMed (effective January 19, 2026, Amneal Pharmaceuticals LLC); the palonosetron FDA label on DailyMed (effective April 29, 2025, Avyxa Pharma, LLC).
What does the cyclophosphamide label say about palonosetron?
Cyclophosphamide's label (effective January 19, 2026) and its 3 other brand-application labels do not name palonosetron in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cyclophosphamide), Amneal Pharmaceuticals LLC, effective January 19, 2026 (SPL set 520bfe39-dfd5-4a20-9a37-80078afded0d), via openFDA; the full label on DailyMed
What does the palonosetron label say about cyclophosphamide?
Palonosetron Hydrochloride label (Cipla USA Inc., January 13, 2022), drug interactionsPalonosetron did not inhibit the antitumor activity of the five chemotherapeutic agents tested (cisplatin, cyclophosphamide, cytarabine, doxorubicin and mitomycin C) in murine tumor models.
Source: FDA drug label (Palonosetron Hydrochloride, NDA021372), Cipla USA Inc., effective January 13, 2022 (SPL set 37e7ef89-fd77-44e0-9271-ae91f8822603), via openFDA
Source: FDA drug label (posfrea), Avyxa Pharma, LLC, effective April 29, 2025 (SPL set 13a201ba-c86d-48c5-a0e1-a3e0b4e6a2a7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclophosphamide | Palonosetron | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Nausea and vomiting |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.67 per capsule 50 mg capsule | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once