What the FDA labels say about taking them together
Cyclophosphamide and indomethacin
Cyclophosphamide's FDA label (Frindovyx) of August 26, 2026 names indomethacin in its drug interactions section; the indomethacin labels PlainMeds reads (4) do not name cyclophosphamide. The cyclophosphamide label: “… ● Amiodarone ● G-CSF, GM-CSF Increased nephrotoxicity ● Amphotericin B ● Indomethacin:”
Check it at the source: the cyclophosphamide FDA label on DailyMed (effective January 19, 2026, Amneal Pharmaceuticals LLC); the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the cyclophosphamide label say about indomethacin?
Frindovyx label (AVYXA Pharma, LLC, August 26, 2026), drug interactionsACE inhibitors can cause leukopenia. ● Natalizumab ● Paclitaxel: Increased hematotoxicity has been reported when cyclophosphamide was administered after paclitaxel infusion. ● Thiazide diuretics ● Zidovudine Increased cardiotoxicity ● Anthracyclines ● Cytarabine ● Pentostatin ● Radiation therapy of the cardiac region ● Trastuzumab Increased pulmonary toxicity ● Amiodarone ● G-CSF, GM-CSF (granulocyte colony-stimulating factor, granulocyte macrophage colony-stimulating factor) Increased nephrotoxicity ● Amphotericin B ● Indomethacin:
Cyclophosphamide label (Eugia US LLC, April 21, 2025), drug interactionsToxicity: Increased nephrotoxicity; Drugs: Amphotericin B Indomethacin: Acute water intoxication has been reported with concomitant use of indomethacin
Source: FDA drug label (Frindovyx, NDA210852), AVYXA Pharma, LLC, effective August 26, 2026 (SPL set 5ad8ea65-4c98-487a-9c8d-df778765ec5e), via openFDA
Source: FDA drug label (Cyclophosphamide, NDA210735), Eugia US LLC, effective April 21, 2025 (SPL set 3c1eb470-0bba-457d-94e3-b9508f0d398a), via openFDA
Source: FDA drug label (Cyclophosphamide), Amneal Pharmaceuticals LLC, effective January 19, 2026 (SPL set 520bfe39-dfd5-4a20-9a37-80078afded0d), via openFDA; the full label on DailyMed
What does the indomethacin label say about cyclophosphamide?
Indomethacin's label (effective December 19, 2025) and its 3 other brand-application labels do not name cyclophosphamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclophosphamide | Indomethacin | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.67 per capsule 50 mg capsule | $0.210 per capsule 75 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once