What the FDA labels say about taking them together
Cyclophosphamide and idarubicin
Idarubicin's FDA label of May 9, 2025 names cyclophosphamide in its warnings section; the cyclophosphamide labels PlainMeds reads (4) do not name idarubicin. The idarubicin label: “The risk of such myocardial toxicity may be higher following concomitant or previous radiation to the mediastinal-pericardial area or in patients with anemia, bone marrow depression, infections, leukemic pericarditis …”
Check it at the source: the cyclophosphamide FDA label on DailyMed (effective January 19, 2026, Amneal Pharmaceuticals LLC); the idarubicin FDA label on DailyMed (effective May 9, 2025, Meitheal Pharmaceuticals Inc.).
What does the cyclophosphamide label say about idarubicin?
Cyclophosphamide's label (effective January 19, 2026) and its 3 other brand-application labels do not name idarubicin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cyclophosphamide), Amneal Pharmaceuticals LLC, effective January 19, 2026 (SPL set 520bfe39-dfd5-4a20-9a37-80078afded0d), via openFDA; the full label on DailyMed
What does the idarubicin label say about cyclophosphamide?
Idarubicin label, warningsThe risk of such myocardial toxicity may be higher following concomitant or previous radiation to the mediastinal-pericardial area or in patients with anemia, bone marrow depression, infections, leukemic pericarditis and/or myocarditis, active or dormant cardiovascular disease, previous therapy with other anthracyclines or anthracenediones, and concomitant use of drugs with the ability to suppress cardiac contractility or cardiotoxic drugs (e.g., trastuzumab, cyclophosphamide and paclitaxel).
Source: FDA drug label (Idarubicin Hydrochloride), Meitheal Pharmaceuticals Inc., effective May 9, 2025 (SPL set d31254be-6bd2-4ac1-acab-bc00e2209d28), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclophosphamide | Idarubicin | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.67 per capsule 50 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once