What the FDA labels say about taking them together
Cyclophosphamide and cyclosporine
Cyclophosphamide's FDA label of January 19, 2026 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name cyclophosphamide. The cyclophosphamide label: “Cyclosporine Concomitant administration of cyclophosphamide may decrease serum concentrations of cyclosporine.”
Check it at the source: the cyclophosphamide FDA label on DailyMed (effective January 19, 2026, Amneal Pharmaceuticals LLC); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the cyclophosphamide label say about cyclosporine?
Cyclophosphamide label, drug interactionsCyclosporine Concomitant administration of cyclophosphamide may decrease serum concentrations of cyclosporine.
Cyclophosphamide label (Eugia US LLC, April 21, 2025), drug interactionsCyclosporine Lower serum concentrations of cyclosporine have been observed in patients receiving a combination of cyclophosphamide and cyclosporine than in patients receiving only cyclosporine.
Source: FDA drug label (Cyclophosphamide, NDA210735), Eugia US LLC, effective April 21, 2025 (SPL set 3c1eb470-0bba-457d-94e3-b9508f0d398a), via openFDA
Source: FDA drug label (Cyclophosphamide), Amneal Pharmaceuticals LLC, effective January 19, 2026 (SPL set 520bfe39-dfd5-4a20-9a37-80078afded0d), via openFDA; the full label on DailyMed
What does the cyclosporine label say about cyclophosphamide?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name cyclophosphamide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclophosphamide | Cyclosporine | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.67 per capsule 50 mg capsule | $1.04 per unit 0.05% eye emulsion |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once