What the FDA labels say about taking them together
Cyclopentolate and pilocarpine
Cyclopentolate's FDA label of June 25, 2024 names pilocarpine in its drug interactions section; the pilocarpine labels PlainMeds reads (3) do not name cyclopentolate.
Check it at the source: the cyclopentolate FDA label on DailyMed (effective June 25, 2024, Alcon Laboratories, Inc.); the pilocarpine FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the cyclopentolate label say about pilocarpine?
Cyclopentolate label, drug interactionsDrug Interactions: Cyclopentolate may interfere with the ocular anti-hypertensive action of carbachol, pilocarpine, or ophthalmic cholinesterase inhibitors.
Source: FDA drug label (Cyclogyl), Alcon Laboratories, Inc., effective June 25, 2024 (SPL set 1d008c76-7210-4ace-90fa-7cd22762e12e), via openFDA; the full label on DailyMed
What does the pilocarpine label say about cyclopentolate?
Pilocarpine's label (effective December 5, 2024) and its 2 other brand-application labels do not name cyclopentolate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Salagen), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set 62eda83d-d043-4c7e-8fcf-75d05efbf35b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclopentolate | Pilocarpine | |
|---|---|---|
| Labeled for | n/a | Glaucoma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $2.65 per mL 1% eye drops | $0.338 per tablet 5 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once