What the FDA labels say about taking them together
Corticotropin and mitotane
Mitotane's FDA label of March 3, 2026 names corticotropin in its warnings and precautions section; the corticotropin labels PlainMeds reads (2) do not name mitotane. The mitotane label: “Due to increased steroid clearance and increase of steroid-binding protein, high-dose replacement therapy may be required and free cortisol and corticotropin (ACTH) should be monitored to adapt the systemic …”
Check it at the source: the corticotropin FDA label on DailyMed (effective July 15, 2026, Mallinckrodt ARD LLC); the mitotane FDA label on DailyMed (effective March 3, 2026, ESTEVE PHARMACEUTICALS, S.A.).
What does the corticotropin label say about mitotane?
Corticotropin's label (effective July 15, 2026) and its 1 other brand-application label do not name mitotane in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Acthar), Mallinckrodt ARD LLC, effective July 15, 2026 (SPL set 7b48ddec-e815-45f4-9ca0-5c0daaf56f30), via openFDA; the full label on DailyMed
What does the mitotane label say about corticotropin?
Mitotane label, warnings and precautionsDue to increased steroid clearance and increase of steroid-binding protein, high-dose replacement therapy may be required and free cortisol and corticotropin (ACTH) should be monitored to adapt the systemic corticosteroids.
Source: FDA drug label (Lysodren), ESTEVE PHARMACEUTICALS, S.A., effective March 3, 2026 (SPL set 4046a224-8832-daa2-e063-6294a90a11d7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Corticotropin | Mitotane | |
|---|---|---|
| Labeled for | Multiple sclerosis, Psoriasis, Eczema (atopic dermatitis) | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once