What the FDA labels say about taking them together
Estrogens conjugated and testosterone
Estrogens conjugated's FDA label of June 4, 2026 names testosterone in its warnings and precautions section; the testosterone labels PlainMeds reads (4) do not name estrogens conjugated. The estrogens conjugated label: “Free hormone concentrations, such as testosterone and estradiol, may be decreased.”
Check it at the source: the estrogens conjugated FDA label on DailyMed (effective June 4, 2026, Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.); the testosterone FDA label on DailyMed (effective July 25, 2025, Azurity Pharmaceuticals, Inc.).
What does the estrogens conjugated label say about testosterone?
Estrogens conjugated label, warnings and precautionsFree hormone concentrations, such as testosterone and estradiol, may be decreased.
Source: FDA drug label (Premarin), Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective June 4, 2026 (SPL set 258e1602-a3cf-4ccc-ca80-73dbbfb812ff), via openFDA; the full label on DailyMed
What does the testosterone label say about estrogens conjugated?
Testosterone's label (effective July 25, 2025) and its 3 other brand-application labels do not name estrogens conjugated in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (AZMIRO), Azurity Pharmaceuticals, Inc., effective July 25, 2025 (SPL set 235b5625-570d-3fba-e063-6394a90aa2d1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Estrogens conjugated | Testosterone | |
|---|---|---|
| Labeled for | Menopause symptoms, Breast cancer, Osteoporosis | Breast cancer |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $5.47 per tablet 0.625 mg tablet | $11.39 per mL 200 mg/mL |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once